Is LDL Bad?

The gold standard of hammering down the cholesterol may be in question…..again.   A new study may show that there could be a correlation between a low LDL and cancer.   Others study have shown this but there was some confusion about whether it was related to the medicine people were taking.  In this study, no one was on meds and the relationship was still there.  Wow.  This is all still preliminary but it will send shockwaves around the medical world.   Remember, our first job is to do no harm.   Maybe we need to take this out of the cardiologists’ hands and look at the use of statins from a 30,000 feet level?   LDL is not bad.  Small, dense LDL is bad.  Bad diets lead to LDL being oxidized from a fluffy buoyant configuration to a small, dense one.  Maybe we need to stop estimating LDL and directly measure small, dense LDL to get a better studies?

Douglas Farrago MD

Douglas Farrago MD is a full-time practicing family doc in Forest, Va. He started Forest Direct Primary Care where he takes no insurance and bills patients a monthly fee. He is board certified in the specialty of Family Practice. He is the inventor of a product called the Knee Saver which is currently in the Baseball Hall of Fame. The Knee Saver and its knock-offs are worn by many major league baseball catchers. He is also the inventor of the CryoHelmet used by athletes for head injuries as well as migraine sufferers. Dr. Farrago is the author of four books, two of which are the top two most popular DPC books. From 2001 – 2011, Dr. Farrago was the editor and creator of the Placebo Journal which ran for 10 full years. Described as the Mad Magazine for doctors, he and the Placebo Journal were featured in the Washington Post, US News and World Report, the AP, and the NY Times. Dr. Farrago is also the editor of the blog Authentic Medicine which was born out of concern about where the direction of healthcare is heading and the belief that the wrong people are in charge. This blog has been going daily for more than 15 years Article about Dr. Farrago in Doximity Email Dr. Farrago – [email protected] 

  1 comment for “Is LDL Bad?

  1. March 29, 2012 at 3:36 pm

    how about this for a 30,000ft view:
    1.the study linking cholesterol to heart disease was done by keys, called the seven countries study. too bad the study was originally done in 15 countries, and 8 of the countries that were studied showed no correlation between cholesterol and heart disease and were consequently omitted.
    2.cholesterol has also been shown to be protective against death from sepsis is some animal models
    3.while there are studies showing secondary prevention works, they have never actually treated based on an LDL level, but rather whether or not you had an MI or stroke.
    4.there are two trials done on primary prevention, one done in japan (therefore likely not applicable to the us and done with pravastatin) and the other (jupiter) that was stopped early before regression to the mean had erased any slight mortality benefit that it showed
    5.noone has prospectively validated framingham in a study and proven mortality reduction
    6.all other cholesterol medicines, diets and such have shown NO mortality benefit, ever.
    7.even if JUPITER were true, it would cost $600,000 per life saved if we followed that protocol for prevention. the current set point for efficacy is ~$150,000.
    so, as George Carlin would have said, “We made the whole f*&^%$g thing up! Aren’t we versatile?”
    Read about it more in the Scandinavian Cardiovascular Journal. A fine, nondrug company, non conflicted publication.

Comments are closed.